IN VITRO EVALUATION OF ANTITHROMBOTIC AND ANTICOAGULANT ACTIVITY OF HERBAL SOURCES

Objective: In vitro evaluate the antiaggregation and anticoagulation properties of aqueous plant extracts, including Viburnum opulus flowers and fruits, Urtica dioica leaves, Coffea arabica leaves, and shepherd's purse (Capsella bursa-pastoris) herb. Methods: In vitro assessment of anticoagulation activity was conducted by examining the impact on activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen levels. Anti-aggregation activity was evaluated using the Born turbidimetric method. Results: The research found that the phytoextracts examined did not impact the concentration of fibrinogen and PT. However, they did slightly prolong the APTT, and this effect was statistically significant compared to the control. Coffea arabica leaves, and Viburnum opulus fruit extracts showed substantial anticoagulant activity (30% and 29% sodium heparin, respectively; p-value