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Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations

Authors :
Elliott Rees
Hugo D. J. Creeth
Hai-Gwo Hwu
Wei J. Chen
Ming Tsuang
Stephen J. Glatt
Romain Rey
George Kirov
James T. R. Walters
Peter Holmans
Michael J. Owen
Michael C. O’Donovan
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Overlapping genes have been implicated in schizophrenia and neurodevelopmental disorders. Here, the authors overlap de novo variants in the two types of disorders and find variants in these genes with the same functional effect and in some cases the same specific variants.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2c5e6d147085447d9cf1e2c12333d3cc
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-25532-4