Back to Search Start Over

Multiple Cell Cultures for MRI Analysis

Authors :
Zuzanna Bober
David Aebisher
Marcin Olek
Aleksandra Kawczyk-Krupka
Dorota Bartusik-Aebisher
Source :
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10109 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Magnetic resonance imaging (MRI) is an imaging method that enables diagnostics. In recent years, this technique has been widely used for research using cell cultures used in pharmaceutical science to understand the distribution of various drugs in a variety of biological samples, from cellular models to tissues. MRI’s dynamic development in recent years, in addition to diagnostics, has allowed the method to be implemented to assess response to applied therapies. Conventional MRI imaging provides anatomical and pathological information. Due to advanced technology, MRI provides physiological information. The use of cell cultures is very important in the process of testing new synthesized drugs, cancer research, and stem cell research, among others. Two-dimensional (2D) cell cultures conducted under laboratory conditions, although they provide a lot of information, do not reflect the basic characteristics of the tumor. To replicate the tumor microenvironment in science, a three-dimensional (3D) culture of tumor cells was developed. This makes it possible to reproduce in vivo conditions where, in addition, there is a complex and dynamic process of cell-to-cell communication and cell–matrix interaction. In this work, we reviewed current research in 2D and 3D cultures and their use in MRI studies. Articles for each section were collected from PubMed, ScienceDirect, Web of Science, and Google Scholar.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
23
Issue :
17
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.2c98874a92d14c99b2126dbcd0933a3a
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms231710109