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A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Mutations that lead to misfolding of rhodopsin can cause retinitis pigmentosa. Here, the authors carry out a high throughput screen to identify a small molecule chaperone of rod opsin, and show that it protects mouse models of retinitis pigmentosa from retinal degeneration.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2d584c977cb4762bef27d1675ed8e92
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-04261-1