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CD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation

Authors :
Gentaro Izumi
Hideki Nakano
Keiko Nakano
Gregory S. Whitehead
Sara A. Grimm
Michael B. Fessler
Peer W. Karmaus
Donald N. Cook
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Dendritic cells in the lung may be specialised to mediate specific types of immune function. Here the authors show that subpopulations of mouse CD11b+ lung DC at different stages of maturation and phenotype can promote Th17 or Th2 CD4+ T cell differentiation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2d7e7a34ad9741c7b9cd97853b90ab3b
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-25307-x