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A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

Authors :
Sisi Kang
Mei Yang
Suhua He
Yueming Wang
Xiaoxue Chen
Yao-Qing Chen
Zhongsi Hong
Jing Liu
Guanmin Jiang
Qiuyue Chen
Ziliang Zhou
Zhechong Zhou
Zhaoxia Huang
Xi Huang
Huanhuan He
Weihong Zheng
Hua-Xin Liao
Fei Xiao
Hong Shan
Shoudeng Chen
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

While SARS-CoV-2 S protein targeting monoclonal antibodies (mAbs) are well studied, little is known about N protein-targeting mAbs. Here, Kang et al. provide the crystal structure of the N protein RNA binding domain with a mAb derived from a convalescent patient and show that it compromises the N protein-induced complement hyperactivation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2da4437eaadf4c83b43c76e7bb299f22
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-23036-9