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Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

Authors :
Thomas Rasmussen
Robin de Nijs
Lene Kjær Olsen
Anne-Lise Kamper
Lia Evi Bang
Marie Frimodt-Møller
Henning Kelbæk
Søren Schwartz Sørensen
Andreas Kjær
Bo Feldt-Rasmussen
Jesper Hastrup Svendsen
Philip Hasbak
Source :
Diagnostics, Vol 10, Iss 10, p 802 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.

Details

Language :
English
ISSN :
20754418
Volume :
10
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.2ddaf8f7f5e40f9b6418b43923b1ca8
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics10100802