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Von Willebrand Factor Antigen Predicts Response to Double Dose of Aspirin and Clopidogrel by PFA-100 in Patients Undergoing Primary Angioplasty for St Elevation Myocardial Infarction
- Source :
- The Scientific World Journal, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Von Willebrand factor (VWF) is an emerging risk factor in acute coronary syndromes. Platelet Function Analyzer (PFA-100) with Collagen/Epinephrine (CEPI) is sensitive to functional alterations of VWF and also identifies patients with high on-treatment platelet reactivity (HPR). The objective of this study was to verify the effect of double dose (DD) of aspirin and clopidogrel on HPR detected by PFA-100 and its relation to VWF and to its regulatory metalloprotease ADAMTS-13. Between 2009 and 2011 we enrolled 116 consecutive patients with ST elevation myocardial infarction undergoing primary PCI with HPR at day 5 after PCI. Patients recruited were then randomized between a standard dose (SD, n=58) or DD of aspirin and clopidogrel (DD, n=58), maintained for 6 months follow-up. Blood samples for PFA-100, light transmittance aggregometry, and VWF/ADAMTS-13 analysis were collected after 5, 30, and 180 days (Times 0, 1, and 2). At Times 1 and 2 we observed a significantly higher CEPI closure times (CT) in DD as compared to SD (P
- Subjects :
- Technology
Medicine
Science
Subjects
Details
- Language :
- English
- ISSN :
- 1537744X
- Volume :
- 2013
- Database :
- Directory of Open Access Journals
- Journal :
- The Scientific World Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2e148f957e7f44dfa284919cfd8fb961
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2013/313492