Apolipoprotein E gene polymorphism in Egyptian acute coronary syndrome patients

Background: Apolipoprotein E (apo E) gene polymorphism was found to be associated with coronary artery disease in several studies. In this investigation, we aimed to study the association between apo E gene polymorphism and acute coronary syndrome in Egyptian population. Subjects and methods: The study included 200 patients with acute coronary syndrome (myocardial infarction and unstable angina), and 100 healthy controls. Anthropometric, clinical and lipid profile parameters were evaluated. Apo E genotyping was carried out using sequence-specific-primer (SSP)-PCR methodology. Results: Є3/4 genotype frequency was higher in the patients than in the controls (P