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Malignancy is increased in patients with antineutrophil cytoplasmic antibody-associated vasculitis in China
- Source :
- Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-8 (2024)
- Publication Year :
- 2024
- Publisher :
- BMC, 2024.
-
Abstract
- Abstract Objective It has been reported that in western countries malignancy risk was higher in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) compared with that in the general population. In the current study, we investigated the incidence, spectrum and risk factors of malignancy in Chinese AAV patients. Methods AAV patients diagnosed from 1995 to 2021 in Peking University First Hospital with a follow-up more than 12 months were recruited. Standardized incidence ratios (SIR) were calculated to describe the risk of malignancy, adjusted for sex, age and follow-up time. Results A total of 552 AAV patients were recruited, among which 23 patients had malignancies either preceding or concurrent with AAV diagnosis, and 43 of the remaining 529 patients developed malignancies within 4.3 ± 4.2 years post AAV diagnosis (SIR: 2.24; 95% CI: 1.68–2.99; p
Details
- Language :
- English
- ISSN :
- 14786362 and 68099274
- Volume :
- 26
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Arthritis Research & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2e2ac68099274ddd96c3fc013d028f77
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s13075-024-03345-2