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Prevention of diabetes in hypertensive patients: Results and implications from the VALUE trial
- Source :
- Vascular Health and Risk Management, Vol 2009, Iss default, Pp 361-368 (2009)
- Publication Year :
- 2009
- Publisher :
- Dove Medical Press, 2009.
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Abstract
- Ming-Sheng Zhou, Ivonne Hernandez SchulmanNephrology-Hypertension Section, Veterans Affairs Medical Center and Division of Nephrology and Hypertension and Vascular Biology institute, University of Miami Miller School of Medicine, Miami, FL, USAAbstract: A growing number of experimental and clinical studies have provided evidence indicating that pharmacological blockade of the renin–angiotensin system (RAS) by either angiotensin-converting enzyme inhibitors or angiotensin type 1 receptor blockers reduces the incidence of new onset type 2 diabetes in subjects with hypertension and/or cardiovascular disease, independently of antihypertensive and cardiovascular protective effects. The beneficial effects of RAS inhibition on the development of diabetes have been largely attributed to improvements in peripheral insulin sensitivity and glucose metabolism. This review focuses on recent experimental and clinical evidence supporting the role of RAS inhibition in the reduction of new onset type 2 diabetes and the mechanisms that may be involved.Keywords: renin–angiotensin system, antihypertensive, diabetes
- Subjects :
- Diseases of the circulatory (Cardiovascular) system
RC666-701
Subjects
Details
- Language :
- English
- ISSN :
- 11766344 and 11782048
- Volume :
- 2009
- Issue :
- default
- Database :
- Directory of Open Access Journals
- Journal :
- Vascular Health and Risk Management
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2e4f7f99e94d849d955d9d5da75bf0
- Document Type :
- article