Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.

Authors :: Naowarat Tanomsing
Mayfong Mayxay
Paul N Newton
Francois Nosten
Christiane Dolecek
Tran Tinh Hien
Nicholas J White
Nicholas P J Day
Arjen M Dondorp
Mallika Imwong
Source :: PLoS ONE, Vol 9, Iss 4, p e93942 (2014)
Publication Year :: 2014
Publisher :: Public Library of Science (PLoS), 2014.
Abstract: The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.

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