Impact of Asymptomatic Neurosyphilis on Patients Quality of Life and Social Stigma

Guiping Li,1 Kamran Ali,2 Xiujun Gao,1 Sha Lu,1 Weiqin xu,1 Xiaoying Zhu1 1Mental Health Center Affiliated Hangzhou Seventh People’s Hospital Zhejiang University School of Medicine, Hangzhou, 310013, People’s Republic of China; 2Department of Dermatology, International Education College of Zhejiang Chinese Medical University, Hangzhou, 310006, People’s Republic of ChinaCorrespondence: Xiaoying Zhu, Mental Health Center Affiliated Hangzhou Seventh People’s Hospital Zhejiang University School of Medicine, Hangzhou, 310013, People’s Republic of China, Email m18957118053_2@163.comBackground/Objectives: Neurosyphilis is a disease caused by Treponema pallidum when it invades the central nervous system. Asymptomatic neurosyphilis (ANS) is one of the most common types of neurosyphilis, however it is often misdiagnosed. This study aimed to explore the impact of ANS on patient’s quality of life and social stigma.Methods: A total of 159 ANS patients were diagnosed by their serology and cerebrospinal fluid. These patients’ stigma and quality of life were assessed separately through the Social Impact Scale (SIS) and the Easy Response Questionnaire.Results: The average age was 36.25± 8.36 years old, and 114 patients were males (71.69%). The serum syphilis test of 159 selected patients was positive, and the indicators of nucleus cells, protein quantification, and syphilis antibodies in the cerebrospinal fluid met the criteria for ANS. The total stigma score was (40.23 ± 10.12), with the scores of the different entries being clearly differentiated, with the highest being the 15th entry (I feel I need to keep my illness a secret), with an average score of 3.15/4.Conclusion: Patients with asymptomatic neurosyphilis may feel social stigma and are more negative when facing their disease. Health-care workers should be aware of the particular aspects of their condition and pay special attention to the need for patient privacy.Keywords: neurosyphilis, asymptomatic neurosyphilis, social stigma, quality of life, social impact scale, sexually transmitted diseases