Back to Search
Start Over
Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis
- Source :
- GMS German Medical Science, Vol 9, p Doc11 (2011)
- Publication Year :
- 2011
- Publisher :
- German Medical Science GMS Publishing House, 2011.
-
Abstract
- We analyzed clinical outcome of patients with an isolated central nervous system lymphoma (CNSL) relapse after systemic non-Hodgkin’s lymphoma (NHL). All 23 patients with an isolated secondary CNSL (SCNSL) treated at two institutions from 04/2003–12/2007 were included into this analysis. At cerebral relapse, 15/23 patients were treated with a regimen consisting of high-dose methotrexate (Bonn protocol). After a median follow-up of 6.5 months (range 1–68), 15/23 (65%) patients with SCNSL had relapsed or progressed. HD (high-dose)- methotrexate (MTX) chemotherapy according to the Bonn protocol is effective concerning response rates; however, overall survival of patients with SCNSL seems to be impaired in comparison to relapses in primary CNSL (PCNSL).
- Subjects :
- lymphoma
neoplasia
chemotherapy
CNS
relapse
methotrexate
Medicine
Subjects
Details
- Language :
- German, English
- ISSN :
- 16123174
- Volume :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- GMS German Medical Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2e92555b387b487bb51794fc2ce8bad0
- Document Type :
- article