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Epidemiology, Clinical Features and Prognostic Factors of Pediatric SARS-CoV-2 Infection: Results From an Italian Multicenter Study

Authors :
Silvia Garazzino
Andrea Lo Vecchio
Luca Pierantoni
Francesca Ippolita Calò Carducci
Federico Marchetti
Antonella Meini
Elio Castagnola
Gianluca Vergine
Daniele Donà
Samantha Bosis
Icilio Dodi
Elisabetta Venturini
Enrico Felici
Roberta Giacchero
Marco Denina
Luca Pierri
Giangiacomo Nicolini
Carlotta Montagnani
Andrzej Krzysztofiak
Sonia Bianchini
Caterina Marabotto
Pier-Angelo Tovo
Giulia Pruccoli
Marcello Lanari
Alberto Villani
Guido Castelli Gattinara
The Italian SITIP-SIP Pediatric Infection Study Group
Valeria Caldarelli
Filippo Maria Salvini
Giovanni Corsello
Barba Paolo Del
Paola Berlese
Carlo Agostoni
Chiara Ghizzi
Vera Quadri
Sara Riscassi
Ivana Rabbone
Carmelina Calitri
Luisa Abbagnato
Luciana Parola
Giuseppe Banderali
Ilaria Pacati
Simonetta Cherubini
Paola Lippi
Andrea Guala
Rino Agostiniani
Salvatore Cazzato
Ahmad Kantar
Luca Baroero
Nadia Rossi
Cristina Dalmazzo
Laura Panigati
Paolo Manzoni
Alessandro Vigo
Ludovica Fiore
Pasquale Comberiati
Gianna Battezzati
Paola Verna
Gianluca Tornese
Paola Gianino
Luca Bertacca
Angelina Vaccaro
Giorgio Zavarise
Luigi Marchione
Paola Gallia
Paola Di Filippo
Chiara Centenari
Alessandra Iacono
Alessandro Plebani
Marta Ferretti
Sara Rizzi
Sara Rossin
Paola Marchisio
Alessandro De Fanti
Costantino De Giacomo
Giuliana Ferrante
Graziano Barera
Pajno Roberta
Stefano Martelossi
Alessia Rocchi
Rosa Francavilla
Valin Paola Sogno
Marco Poeta
Piero Valentini
Raffaele Papa
Anna Maria Magistà
Raffaele Badolato
Carolina Saffioti
Maria Cristina Greco
Paola Costenaro
Maria Di Pietro
Susanna Esposito
Giovanni Pieri
Maria Valentina Spartà
Valentina Maffini
Laura Cursi
Francesco Nunziata
Federica Mignone
Claudia Bondone
Giacomo Stera
Agostina Marolda
Lorenzo Fiorica
Caterina Sabatini
Maria Rita Genovese
Cristina Ferrari
Luisa Galli
Source :
Frontiers in Pediatrics, Vol 9 (2021)
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

Background: Many aspects of SARS-CoV-2 infection in children and adolescents remain unclear and optimal treatment is debated. The objective of our study was to investigate epidemiological, clinical and therapeutic characteristics of pediatric SARS-CoV-2 infection, focusing on risk factors for complicated and critical disease.Methods: The present multicenter Italian study was promoted by the Italian Society of Pediatric Infectious Diseases, involving both pediatric hospitals and general pediatricians/family doctors. All subjects under 18 years of age with documented SARS-CoV-2 infection and referred to the coordinating center were enrolled from March 2020.Results: As of 15 September 2020, 759 children were enrolled (median age 7.2 years, IQR 1.4; 12.4). Among the 688 symptomatic children, fever was the most common symptom (81.9%). Barely 47% of children were hospitalized for COVID-19. Age was inversely related to hospital admission (p < 0.01) and linearly to length of stay (p = 0.014). One hundred forty-nine children (19.6%) developed complications. Comorbidities were risk factors for complications (p < 0.001). Viral coinfections, underlying clinical conditions, age 5–9 years and lymphopenia were statistically related to ICU admission (p < 0.05).Conclusions: Complications of COVID-19 in children are related to comorbidities and increase with age. Viral co-infections are additional risk factors for disease progression and multisystem inflammatory syndrome temporarily related to COVID-19 (MIS-C) for ICU admission.

Details

Language :
English
ISSN :
22962360
Volume :
9
Database :
Directory of Open Access Journals
Journal :
Frontiers in Pediatrics
Publication Type :
Academic Journal
Accession number :
edsdoj.2ec8e367cab847efa6b8f95c3ad14d34
Document Type :
article
Full Text :
https://doi.org/10.3389/fped.2021.649358