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Non-coding RNAs in acute ischemic stroke: from brain to periphery

Authors :
Shuo Li
Zhaohan Xu
Shiyao Zhang
Huiling Sun
Xiaodan Qin
Lin Zhu
Teng Jiang
Junshan Zhou
Fuling Yan
Qiwen Deng
Source :
Neural Regeneration Research, Vol 20, Iss 1, Pp 116-129 (2025)
Publication Year :
2025
Publisher :
Wolters Kluwer Medknow Publications, 2025.

Abstract

Acute ischemic stroke is a clinical emergency and a condition with high morbidity, mortality, and disability. Accurate predictive, diagnostic, and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain undetermined. With innovations in high-throughput gene sequencing analysis, many aberrantly expressed non-coding RNAs (ncRNAs) in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental models. Differentially expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes, leading to neuroprotection or deterioration, thus ncRNAs can serve as therapeutic targets in acute ischemic stroke. Moreover, distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction, diagnosis, and prognosis. In particular, ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic stroke. In this review, we consolidate the latest progress of research into the roles of ncRNAs (microRNAs, long ncRNAs, and circular RNAs) in the pathological processes of acute ischemic stroke–induced brain damage, as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction, diagnosis, and prognosis. Findings from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

Details

Language :
English
ISSN :
16735374 and 18767958
Volume :
20
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Neural Regeneration Research
Publication Type :
Academic Journal
Accession number :
edsdoj.2f65dbb01b3244d6b24aa644306657cb
Document Type :
article
Full Text :
https://doi.org/10.4103/NRR.NRR-D-23-01292