Two Cases of Immune Drift Phenomena Caused by Biologic Agents for Treating Psoriasis and Atopic Dermatitis

Xiaolei Ma,1 Tianying Li,2 Gangwen Han1 1Department of Dermatology, Peking University International Hospital, Beijing, People’s Republic of China; 2Department of Pathology, Peking University International Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xiaolei Ma, Peking University International Hospital, Life Park Road No. 1 Life Science Park of Zhong Guancun, Chang Ping District, Beijing, People’s Republic of China, Email superma.xiaolei@163.comAbstract: Atopic dermatitis and psoriasis are both common chronic inflammatory skin conditions that can significantly affect the quality of life for individuals affected by them. With the growing use of biologic agents, there have been remarkable clinical advancements in the treatment of these diseases. Interestingly, during biologic therapy for either condition, a phenomenon has emerged where treatment can paradoxically induce a transition to the phenotype of the other condition.We present two cases of immune drift phenomena caused by biologic agents for treating psoriasis and atopic dermatitis.The first one is a case of psoriasis lesion that developed in an old patient with AD who was treated with dupilumab for two months. The second one is a case of eczematoid lesion that developed in an adult patient with ankylosing spondylitis who was treated with Secukinumab for 1 year.Keywords: immune drift phenomena, secukinumab, dupilumab, psoriasis and atopic dermatitis