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DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer

Authors :
Dehai Wang
Zhongbo Li
Xin Li
Cheng Yan
Huijie Yang
Ting Zhuang
Xiao Wang
Yifeng Zang
Ziping Liu
Tianshi Wang
Rixia Jiang
Peng Su
Jian Zhu
Yinlu Ding
Source :
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-17 (2022)
Publication Year :
2022
Publisher :
BMC, 2022.

Abstract

Highlights 1. DUB1 is an important modulator of Hippo signaling in gastric cancer. 2. DUB1 expression is elevated in human gastric cancer samples and correlates with poor survival in gastric cancer. 3. DUB1 facilitates gastric cancer progression via the Hippo/TAZ axis. 4. DUB1 associates with TAZ and directly inhibits YAP polyubiquitination and degradation.

Details

Language :
English
ISSN :
17569966
Volume :
41
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Experimental & Clinical Cancer Research
Publication Type :
Academic Journal
Accession number :
edsdoj.2fdc017c5a9c4d9aaef1fa5cec6b80ce
Document Type :
article
Full Text :
https://doi.org/10.1186/s13046-022-02410-5