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Mesenchymal stem cells for repairing glaucomatous optic nerve

Authors :
Bai-Yu Hu
Mei Xin
Ming Chen
Ping Yu
Liu-Zhi Zeng
Source :
International Journal of Ophthalmology, Vol 17, Iss 4, Pp 748-760 (2024)
Publication Year :
2024
Publisher :
Press of International Journal of Ophthalmology (IJO PRESS), 2024.

Abstract

Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells (RGCs) and axons. Currently, there is no effective method to address the cause of RGCs degeneration. However, studies on neuroprotective strategies for optic neuropathy have increased in recent years. Cell replacement and neuroprotection are major strategies for treating glaucoma and optic neuropathy. Regenerative medicine research into the repair of optic nerve damage using stem cells has received considerable attention. Stem cells possess the potential for multidirectional differentiation abilities and are capable of producing RGC-friendly microenvironments through paracrine effects. This article reviews a thorough researches of recent advances and approaches in stem cell repair of optic nerve injury, raising the controversies and unresolved issues surrounding the future of stem cells.

Details

Language :
English
ISSN :
22223959 and 22274898
Volume :
17
Issue :
4
Database :
Directory of Open Access Journals
Journal :
International Journal of Ophthalmology
Publication Type :
Academic Journal
Accession number :
edsdoj.311609893ed64959b47872bfaa2cdf75
Document Type :
article
Full Text :
https://doi.org/10.18240/ijo.2024.04.20