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A Half-Century of Heterotopic Heart Transplantation in Mice: The Spearhead of Immunology Research

Authors :
Decheng Yin
Oliver Dewald
Xiangyu Peng
Wenlong Nie
Song Rong
Diana Dudziak
Christian H. K. Lehmann
André Hoerning
Jian Fu
Source :
Transplantology, Vol 5, Iss 4, Pp 298-311 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Since the success of solid organ transplants, such as human kidneys, livers and hearts, from the 50s to the 60s in the last century, the field of organ transplantation has progressed rapidly. Mainly due to modifications in surgical operation techniques and improvements in immunosuppressive therapy regimes, organ survival time can now be greatly prolonged. This progress has also been dependent upon the availability of appropriate animal models for organ transplantation. Therefore, the mouse heart transplantation model has developed into an irreplaceable research model for solid organ transplantation, providing indelible contributions to the field. In this review, we will provide an overview of the technical developments in murine heart transplantation, as well as its historical and current role for alloimmune research. Further, we will describe its current fields of application and its scientific achievements before we discuss potential future applications.

Details

Language :
English
ISSN :
26733943
Volume :
5
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Transplantology
Publication Type :
Academic Journal
Accession number :
edsdoj.313c7efe0b24a00abb9d7f72ed79302
Document Type :
article
Full Text :
https://doi.org/10.3390/transplantology5040030