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DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here the authors find that DNA methylation at HLA-DRB1 gene mediates the effect of DRB1*15:01 and of a protective HLA variant on HLA-DRB1 expression and the risk of MS.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.31861db392bf46669b4a789c9a333f74
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-04732-5