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Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques

Authors :
Dawn M. Dudley
Christina M. Newman
Joseph Lalli
Laurel M. Stewart
Michelle R. Koenig
Andrea M. Weiler
Matthew R. Semler
Gabrielle L. Barry
Katie R. Zarbock
Mariel S. Mohns
Meghan E. Breitbach
Nancy Schultz-Darken
Eric Peterson
Wendy Newton
Emma L. Mohr
Saverio Capuano III
Jorge E. Osorio
Shelby L. O’Connor
David H. O’Connor
Thomas C. Friedrich
Matthew T. Aliota
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.31917530d7414bac87d6c4b747a76d29
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-02222-8