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Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2

Authors :
Maria D. Ferrer
Álvaro Sánchez Barrueco
Yolanda Martinez-Beneyto
María V. Mateos-Moreno
Verónica Ausina-Márquez
Elisa García-Vázquez
Miguel Puche-Torres
Maria J. Forner Giner
Alfonso Campos González
Jessica M. Santillán Coello
Ignacio Alcalá Rueda
José M. Villacampa Aubá
Carlos Cenjor Español
Ana López Velasco
Diego Santolaya Abad
Sandra García-Esteban
Alejandro Artacho
Xavier López-Labrador
Alex Mira
Source :
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Abstract Most public health measures to contain the COVID-19 pandemic are based on preventing the pathogen spread, and the use of oral antiseptics has been proposed as a strategy to reduce transmission risk. The aim of this manuscript is to test the efficacy of mouthwashes to reduce salivary viral load in vivo. This is a multi-centre, blinded, parallel-group, placebo-controlled randomised clinical trial that tests the effect of four mouthwashes (cetylpyridinium chloride, chlorhexidine, povidone-iodine and hydrogen peroxide) in SARS-CoV-2 salivary load measured by qPCR at baseline and 30, 60 and 120 min after the mouthrinse. A fifth group of patients used distilled water mouthrinse as a control. Eighty-four participants were recruited and divided into 12–15 per group. There were no statistically significant changes in salivary viral load after the use of the different mouthwashes. Although oral antiseptics have shown virucidal effects in vitro, our data show that salivary viral load in COVID-19 patients was not affected by the tested treatments. This could reflect that those mouthwashes are not effective in vivo, or that viral particles are not infective but viral RNA is still detected by PCR. Viral infectivity studies after the use of mouthwashes are therefore required. ( https://clinicaltrials.gov/ct2/show/NCT04707742 ; Identifier: NCT04707742)

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
20452322
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.319c047150b46ca801b342eb8ce1255
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-021-03461-y