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The p53 Mutation/Deletion Profile in a Small Cohort of the Omani Population with Diffuse Large B-Cell Lymphoma

Authors :
Yahya Tamimi
Sheikha Al-Harthy
Ibrahim Al-Haddabi
Mohammed Al-Kindi
Hamza Babiker
Mansour Al-Moundhri
Ikram Burney
Source :
Sultan Qaboos University Medical Journal, Vol 14, Iss 1, Pp 50-58 (2014)
Publication Year :
2014
Publisher :
Sultan Qaboos University, 2014.

Abstract

Objectives: Mutations/deletions affecting the TP53 gene are considered an independent marker predicting a poor prognosis for patients with diffuse large B-cell lymphoma (DLBCL). A cohort within a genetically isolated population was investigated for p53 mutation/deletion status. Methods:Deoxyribonucleic acid (DNA) samples were extracted from 23 paraffin-embedded blocks obtained from DLBCL patients, and subjected to polymerase chain reaction (PCR) amplification and sequencing of exons 4–9 of the p53 gene. Results: While 35% of patients analysed displayed allelic deletions (P

Details

Language :
English
ISSN :
2075051X and 20750528
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Sultan Qaboos University Medical Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.31c8b5d3c60f403c8ef2889165f054bf
Document Type :
article