Back to Search Start Over

Extrinsic Factors Regulating Dendritic Patterning

Authors :
Tzu-Yang Lin
Pei-Ju Chen
Hung-Hsiang Yu
Chao-Ping Hsu
Chi-Hon Lee
Source :
Frontiers in Cellular Neuroscience, Vol 14 (2021)
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

Stereotypic dendrite arborizations are key morphological features of neuronal identity, as the size, shape and location of dendritic trees determine the synaptic input fields and how information is integrated within developed neural circuits. In this review, we focus on the actions of extrinsic intercellular communication factors and their effects on intrinsic developmental processes that lead to dendrite patterning. Surrounding neurons or supporting cells express adhesion receptors and secreted proteins that respectively, act via direct contact or over short distances to shape, size, and localize dendrites during specific developmental stages. The different ligand-receptor interactions and downstream signaling events appear to direct dendrite morphogenesis by converging on two categorical mechanisms: local cytoskeletal and adhesion modulation and global transcriptional regulation of key dendritic growth components, such as lipid synthesis enzymes. Recent work has begun to uncover how the coordinated signaling of multiple extrinsic factors promotes complexity in dendritic trees and ensures robust dendritic patterning.

Details

Language :
English
ISSN :
16625102
Volume :
14
Database :
Directory of Open Access Journals
Journal :
Frontiers in Cellular Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.3260f1a675c48cdb7a824a5f26d66bf
Document Type :
article
Full Text :
https://doi.org/10.3389/fncel.2020.622808