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Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria

Authors :
Bernard Tornyigah
Samuel Odarkwei Blankson
Rafiou Adamou
Azizath Moussiliou
Lauriane Rietmeyer
Patrick Tettey
Liliane Dikroh
Bernard Addo
Helena Lamptey
Maroufou J. Alao
Annick Amoussou
Caroline Padounou
Christian Roussilhon
Sylvie Pons
Benedicta Ayiedu Mensah
Nicaise Tuikue Ndam
Rachida Tahar
Source :
Diagnostics, Vol 12, Iss 2, p 524 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (p < 0.001 for Pentraxine-3, suPAR, and sTie-2, p = 0.004 for PCT, p = 0.005 for sICAM-1, p = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p < 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases.

Details

Language :
English
ISSN :
12020524 and 20754418
Volume :
12
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.32e2271cd9e44e1ca718b78c5b3e0715
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics12020524