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Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.332640b7f2f048bebeba04c9ee651443
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-12094-9