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Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

Authors :
Søs Grønbæk Holdgaard
Valentina Cianfanelli
Emanuela Pupo
Matteo Lambrughi
Michal Lubas
Julie C. Nielsen
Susana Eibes
Emiliano Maiani
Lea M. Harder
Nicole Wesch
Mads Møller Foged
Kenji Maeda
Francesca Nazio
Laura R. de la Ballina
Volker Dötsch
Andreas Brech
Lisa B. Frankel
Marja Jäättelä
Franco Locatelli
Marin Barisic
Jens S. Andersen
Simon Bekker-Jensen
Anders H. Lund
Vladimir V. Rogov
Elena Papaleo
Letizia Lanzetti
Daniela De Zio
Francesco Cecconi
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.332640b7f2f048bebeba04c9ee651443
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-12094-9