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Prognostic value of cystatin C in patients with nasopharyngeal carcinoma: a retrospective study of 1063 patients
- Source :
- Clinics, Vol 71, Iss 6, Pp 338-343
- Publisher :
- Elsevier EspaƱa.
-
Abstract
- OBJECTIVE: Patients with nasopharyngeal carcinoma experience highly variable outcomes despite receiving similar therapeutic regimens. Identifying biomarkers that predict survival and guide individualized therapy is urgently needed. Cystatin C has been explored as a valuable prognostic marker in several malignancies. We retrospectively assessed the relationship between serum cystatin C levels and nasopharyngeal carcinoma prognosis in a large cohort of nasopharyngeal carcinoma patients receiving long-term follow-up. METHODS: A total of 1063 consecutive patients diagnosed with nasopharyngeal carcinoma from June 2006 to December 2010 were retrospectively analyzed. The serum levels of cystatin C at the time of diagnosis were collected. Receiver operating characteristic curve analysis, the Kaplan-Meier method and multivariate analyses using a Cox regression model were performed to assess the correlation of cystatin C levels with overall survival, progression-free survival, distant metastasis-free survival and loco-regional recurrence-free survival. RESULTS: The median follow-up duration was 68.3 months. The optimal cut-off value of cystatin C levels for predicting death was 0.945 mg/L. Compared with the low cystatin C group, the high cystatin C group experienced significantly shorter overall survival (hazard ratio=1.47, p=0.050), progression-free survival (hazard ratio=1.65, p=0.004), distant metastasis-free survival (hazard ratio=2.37, p
- Subjects :
- nasopharyngeal carcinoma
cystatin c
survival
prognosis
Medicine (General)
R5-920
Subjects
Details
- Language :
- English
- ISSN :
- 18075932 and 19805322
- Volume :
- 71
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Clinics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.335bffa7b95b4f1dbe57efcf49d2ef17
- Document Type :
- article
- Full Text :
- https://doi.org/10.6061/clinics/2016(06)09