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PET and PET/CT with 68Gallium-Labeled Somatostatin Analogues in Non GEP-NETs Tumors
- Source :
- The Scientific World Journal, Vol 2014 (2014)
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Somatostatin (SST) is a 28-amino-acid cyclic neuropeptide mainly secreted by neurons and endocrine cells. A major interest for SST receptors (SSTR) as target for in vivo diagnostic and therapeutic purposes was born since a series of stable synthetic SST-analouges PET became available, being the native somatostatin non feasible for clinical use due to the very low metabolic stability. The rationale for the employment of SST-analogues to image cancer is both based on the expression of SSTR by tumor and on the high affinity of these compounds for SSTR. The primary indication of SST-analogues imaging is for neuroendocrine tumors (NETs), which usually express a high density of SSTR, so they can be effectively targeted and visualized with radiolabeled SST-analogues in vivo. Particularly, SST-analogues imaging has been widely employed in gastroenteropancreatic (GEP) NETs. Nevertheless, a variety of tumors other than NETs expresses SSTR thus SST-analogues imaging can also be used in these tumors, particularly if treatment with radiolabeled therapeutic SST-analouges PET is being considered. The aim of this paper is to provide a concise overview of the role of positron emission tomography/computed tomography (PET/CT) with 68Ga-radiolabeled SST-analouges PET in tumors other than GEP-NETs.
- Subjects :
- Technology
Medicine
Science
Subjects
Details
- Language :
- English
- ISSN :
- 23566140 and 1537744X
- Volume :
- 2014
- Database :
- Directory of Open Access Journals
- Journal :
- The Scientific World Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.33e191523524516a7633b0a7b85b673
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2014/194123