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A protein tertiary structure mimetic modulator of the Hippo signalling pathway

Authors :
Hélène Adihou
Ranganath Gopalakrishnan
Tim Förster
Stéphanie M. Guéret
Raphael Gasper
Stefan Geschwindner
Carmen Carrillo García
Hacer Karatas
Ajaybabu V. Pobbati
Mercedes Vazquez‐Chantada
Paul Davey
Carola M. Wassvik
Jeremy Kah Sheng Pang
Boon Seng Soh
Wanjin Hong
Elisabetta Chiarparin
Dennis Schade
Alleyn T. Plowright
Eric Valeur
Malin Lemurell
Tom N. Grossmann
Herbert Waldmann
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEAD:VGL4 interaction in vitro and in cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.34105208594045348e3822ea97b488f7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-19224-8