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Two pyrrole acids isolated from Phyllanthus emblica L. and their bioactivities
- Source :
- Natural Products and Bioprospecting, Vol 13, Iss 1, Pp 1-9 (2023)
- Publication Year :
- 2023
- Publisher :
- SpringerOpen, 2023.
-
Abstract
- Abstract An undescribed pyrrole acid, 1-(4′-methoxy-4′-oxobutyl)-1 H-pyrrole-2,5-dicarboxylic acid (1) and one known pyrrole acid (2) were isolated from the fruits of Phyllanthus emblica. The structures of these compounds were elucidated via the comprehensive analyses of IR, HRESIMS, 1D and 2D spectroscopic data. A series of biological assays revealed that compounds 1 and 2 could inhibit LPS-induced over-production of nitric oxide (NO), interleukin-6 (IL-6), monocyte chemotactic protein 1 (MCP-1) and tumor necrosis factor-α (TNF-α) by reducing the phosphorylation of extracellular regulated protein kinases (ERK) and c-Jun N-terminal kinases (JNK) in RAW 264.7 cells. Additionally, compounds 1 and 2 were found to reduce lipid deposition and increase the mRNA expression of ATP-binding cassette transporter A1 in oxidized low-density lipoprotein-treated RAW264.7 macrophages. Graphical abstract
Details
- Language :
- English
- ISSN :
- 21922195 and 21922209
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Natural Products and Bioprospecting
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.34ca3f3920b45989fae6bff074c3f8f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1007/s13659-023-00393-0