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Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function

Authors :
Conagh J. Kelly
Matthew Chu
Rossana Untaru
Bahador Assadi-Khansari
Dongqing Chen
Amanda J. Croft
John D. Horowitz
Andrew J. Boyle
Aaron L. Sverdlov
Doan T. M. Ngo
Source :
Journal of Cardiovascular Development and Disease, Vol 10, Iss 7, p 274 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels were measured via ELISA in 262 patients admitted to a cardiology unit. Plasma SFRP5 levels were significantly lower in patients with a history of heart failure (HF), coronary artery disease (CAD), and atrial fibrillation (AF; p = 0.001). In univariate analyses, SFRP5 levels were also significantly positively correlated with left ventricular ejection fraction (LVEF) (r = 0.52, p < 0.001) and negatively correlated with E/Eā€™ (r = āˆ’0.30, p < 0.001). Patients with HF, CAD, low LVEF, low triglycerides, high CRP, and high eGFR were associated with lower SFRP5 levels independent of age, BMI, or diabetes after multivariate analysis (overall model r = 0.729, SE = 0.638). Our results show that low plasma SFRP5 levels are independently associated with the presence of HF, CAD, and, importantly, impaired LV function. These results suggest a potential role of SFRP5 as a biomarker, as well as a mediator of cardiac dysfunction independent of obesity and metabolic regulation.

Details

Language :
English
ISSN :
23083425
Volume :
10
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Journal of Cardiovascular Development and Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.34d682bcd9374af0b6b534eca6eef207
Document Type :
article
Full Text :
https://doi.org/10.3390/jcdd10070274