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Non-enzymatic covalent modifications: a new link between metabolism and epigenetics

Authors :
Qingfei Zheng
Igor Maksimovic
Akhil Upad
Yael David
Source :
Protein & Cell, Vol 11, Iss 6, Pp 401-416 (2020)
Publication Year :
2020
Publisher :
Oxford University Press, 2020.

Abstract

Abstract Epigenetic modifications, including those on DNA and histones, have been shown to regulate cellular metabolism by controlling expression of enzymes involved in the corresponding metabolic pathways. In turn, metabolic flux influences epigenetic regulation by affecting the biosynthetic balance of enzyme cofactors or donors for certain chromatin modifications. Recently, non-enzymatic covalent modifications (NECMs) by chemically reactive metabolites have been reported to manipulate chromatin architecture and gene transcription through multiple mechanisms. Here, we summarize these recent advances in the identification and characterization of NECMs on nucleic acids, histones, and transcription factors, providing an additional mechanistic link between metabolism and epigenetics.

Details

Language :
English
ISSN :
1674800X and 16748018
Volume :
11
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Protein & Cell
Publication Type :
Academic Journal
Accession number :
edsdoj.350d58bb43bc427e893cd6482c0b69f7
Document Type :
article
Full Text :
https://doi.org/10.1007/s13238-020-00722-w