Back to Search Start Over

Erythropoetin receptor expression in the human diabetic retina

Authors :
Tsang Stephen H
Shah Shaival S
Mahajan Vinit B
Source :
BMC Research Notes, Vol 2, Iss 1, p 234 (2009)
Publication Year :
2009
Publisher :
BMC, 2009.

Abstract

Abstract Background Recent evidence suggests erythropoietin (EPO) and the erythropoietin receptor (EPOR) may play a direct role in the pathogenesis of diabetic retinopathy. Better characterization of the EPO-EPOR signaling system in the ischemic retina may offer a new therapeutic modality for ischemic ophthalmic diseases. This study was performed to identify EPOR mRNA expression in the human diabetic eye. Findings EPOR antisense RNA probes were validated on human pancreas tissue. In the normal eye, EPOR was expressed in the retinal ganglion cell layer. Minimal expression was observed in the inner and outer nuclear layer. Under conditions of diabetic retinopathy, EPOR expression shifted to photoreceptor cells. Increased expression was also observed in the peripheral retina. Conclusion EPOR expression may be a biomarker or contribute to disease mechanisms in diabetic retinopathy.

Details

Language :
English
ISSN :
17560500
Volume :
2
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Research Notes
Publication Type :
Academic Journal
Accession number :
edsdoj.353f9050921348e4be28fd26c8429c4f
Document Type :
article
Full Text :
https://doi.org/10.1186/1756-0500-2-234