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Recent advances on thermosensitive hydrogels-mediated precision therapy

Authors :
Hao Chen
Jiangmei Xu
Jiangwei Sun
Yongxin Jiang
Wang Zheng
Wei Hu
Haisheng Qian
Source :
Asian Journal of Pharmaceutical Sciences, Vol 19, Iss 3, Pp 100911- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Precision therapy has become the preferred choice attributed to the optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over the past few years, sprayable or injectable thermosensitive hydrogels have exhibited high therapeutic potential. These can be applied as cell-growing scaffolds or drug-releasing reservoirs by simply mixing in a free-flowing sol phase at room temperature. Inspired by their unique properties, thermosensitive hydrogels have been widely applied as drug delivery and treatment platforms for precision medicine. In this review, the state-of-the-art developments in thermosensitive hydrogels for precision therapy are investigated, which covers from the thermo-gelling mechanisms and main components to biomedical applications, including wound healing, anti-tumor activity, osteogenesis, and periodontal, sinonasal and ophthalmic diseases. The most promising applications and trends of thermosensitive hydrogels for precision therapy are also discussed in light of their unique features.

Details

Language :
English
ISSN :
18180876
Volume :
19
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Asian Journal of Pharmaceutical Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.361ffcd9d2bc415fac4d7b2c2d8c5e63
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ajps.2024.100911