IMPROVEMENT OF AMLODIPINE CONTROL EFFICACY OVER HYPERTENSION USING FIXED COMBINATION OF PERINDOPRIL ARGININE AND AMLODIPINE

Aim. To evaluate possibilities of hypertension control improvement using fixed combination of perindopril arginine and amlodipine.Material and methods. Totally 46 patients studied (25 men, 21 women of the age 53,6±4,3y.)with arterial hypertension 2-3 grade. All patients underwent ABPM with analysis of the following: mean 24-hour BP, velocity of morning SBP and DBP rise, BP variability of Ps BP (VPsBPd, VPsBPn).The criteria of inclusion were insufficient control over hypertension while using free combinations of ACE inhibitor or angiotensin II receptor blockers and diuretic or calcium channel blocker. To control arterial hypertension all patients were prescribed the fixed combination of perindopril arginine/amlodipine it standard dosage 10/5 mg (Prestans, "Les Laboratories Servier", France) with further possible increase of dosage up to 10/10 mg.Results. While receiving the therapy 84,7% patients reached "target" BP. Mean 24-hour SBP decreased from 139,24±1,8to 121,13+1,22 mmHg (p