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The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

Authors :
Wenhao Zheng
Xiaofeng Lu
Guangjin Chen
Yufeng Shen
Xiaofei Huang
Jinfeng Peng
Jiajia Wang
Ying Yin
Wencheng Song
Mengru Xie
Shaoling Yu
Lili Chen
Source :
International Journal of Oral Science, Vol 16, Iss 1, Pp 1-11 (2024)
Publication Year :
2024
Publisher :
Nature Publishing Group, 2024.

Abstract

Abstract The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic treatment. However, the sensitivity of existing detection techniques is not sufficient, and the criteria for evaluating optimal force have not been yet established. Here, by employing 3D finite element analysis methodology, we found that the apical distal region (A-D region) of mesial roots is particularly sensitive to orthodontic force in rats. Tartrate-resistant acidic phosphatase (TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams (g), leading to alveolar bone resorption and tooth movement. When the force reached 80 g, TRAP-positive osteoclasts started appearing on the root surface in the A-D region. Additionally, micro-computed tomography revealed a significant root resorption at 80 g. Notably, the A-D region was identified as a major contributor to whole root resorption. It was determined that 40 g is the minimum effective force for tooth movement with minimal side effects according to the analysis of tooth movement, inclination, and hyalinization. These findings suggest that the A-D region with its changes on the root surface is an important consideration and sensitive indicator when evaluating orthodontic forces for a rat model. Collectively, our investigations into this region would aid in offering valuable implications for preventing and minimizing root resorption during patients’ orthodontic treatment.

Subjects

Subjects :
Dentistry
RK1-715

Details

Language :
English
ISSN :
20493169
Volume :
16
Issue :
1
Database :
Directory of Open Access Journals
Journal :
International Journal of Oral Science
Publication Type :
Academic Journal
Accession number :
edsdoj.36bc42d810e5414ea8c4d4936e22fa57
Document Type :
article
Full Text :
https://doi.org/10.1038/s41368-024-00284-1