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MicroRNA-222 Expression and Its Prognostic Potential in Non-Small Cell Lung Cancer
- Source :
- The Scientific World Journal, Vol 2014 (2014)
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Overexpression of miR-222 has been found in several types of cancers; however, the expression of miR-222 in non-small cell lung cancer (NSCLC) and its prognostic values are unclear. This study aimed to investigate whether the miR-222 expression level is related to clinicopathological factors and prognosis of NSCLC. Through a prospective study, 100 pairs of NSCLC tissues and adjacent normal tissues were examined by quantitative reverse-transcription polymerase chain reaction. The correlation between miR-222 expression and clinicopathological features was analyzed, and the significance of miR-222 as a prognostic factor and its relationship with survival were determined. Results showed that the expression levels of miR-222 were significantly elevated in the NSCLC tissue compared with that in adjacent normal tissue. In addition, Cox’s proportional hazards model analysis confirmed that miR-222 high expression level was an independent predictor of poor prognosis. In conclusion, miR-222 overexpression is involved in the poor prognosis of NSCLC and can be used as a biomarker for selection of cases requiring especial attention.
- Subjects :
- Technology
Medicine
Science
Subjects
Details
- Language :
- English
- ISSN :
- 23566140 and 1537744X
- Volume :
- 2014
- Database :
- Directory of Open Access Journals
- Journal :
- The Scientific World Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.36c7fdcf935a4ba78ef20afb7a5ee9c6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2014/908326