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Controlled biodegradation of metallic biomaterials by plasma polymer coatings using hexamethyldisiloxane and allylamine monomers

Authors :
Teske Michael
Wulf Katharina
Fink Joschka
Brietzke Andreas
Arbeiter Daniela
Eickner Thomas
Senz Volkmar
Grabow Niels
Illner Sabine
Source :
Current Directions in Biomedical Engineering, Vol 5, Iss 1, Pp 315-317 (2019)
Publication Year :
2019
Publisher :
De Gruyter, 2019.

Abstract

Plasma enhanced chemical vapor deposition is a promising process for the generation of tailor-made polymer coatings on medical devices in order to improve their implant/ host interaction. The ultra-thin coatings can fulfil a variety of purposes, depending on the monomers used, the process conditions and the location of the coated implants in the human body. In addition, even complex geometries can be coated easily and without the application of solvents. Particularly hydrophilic and hydrophobic plasma polymer coatings can improve biocompatibility, especially in blood contact. Furthermore, the selection of the monomers used enables the generation of specific functional groups for further surface immobilization of drugs, such as proteins, by chemical crosslinking. The release of toxic residues from polymeric implants, such as monomers, additives or degraded components, can also be avoided. The aim of our investigation was the generation of plasma polymer films, their characterization and application as coatings for biodegradable metallic biomaterials in order to retard the degradation process. Metallic biomaterials, in various forms are frequently used in orthopaedics, dentistry, cardiovascular and neurosurgical equipment, because of their tensile strength, fracture toughness, fatigue strength and electrical conductivity. Plasma polymerization was performed using the monomers hexamethyldisiloxane and allylamine. The resulting plasma polymers were analysed in an accelerated degradation test. Both plasma polymers appear to be promising, while polyHMDSO appears to degrade over time and polyallylamine indicates to be stable.

Details

Language :
English
ISSN :
23645504
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Current Directions in Biomedical Engineering
Publication Type :
Academic Journal
Accession number :
edsdoj.373a1915f7574ff2aa96000f017898bc
Document Type :
article
Full Text :
https://doi.org/10.1515/cdbme-2019-0079