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Antibacterial bone cement modified by long-chain nitrofuran methacrylate using liquid-phase modification strategy

Authors :
Hao Lin
Zhe Gao
Lu-Yang Han
Jian-Jun Chu
Yang Xu
Dian-Hong Shen
Source :
Frontiers in Materials, Vol 11 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

A novel acrylic monomer containing a nitrofuran motif, referred to as long-chain nitrofuran methacrylate (LNFMA), is reported. In comparison to the previously reported nitrofuran methacrylate (NFMA), LNFMA has a longer side chain, and when incorporated into bone cement, the resulting LNFMA bone cement exhibits improved mechanical strength. At the same concentration, NFMA-5% cement has only 21.6 ± 1.3 MPa, while LNFMA-5% cement has a compressive strength of 42.64 ± 0.94 MPa. LNFMA bone cements exhibit antimicrobial activity against Staphylococcus aureus, with LNFMA-30% cement reaching 57.38% ± 5.53%. Moreover, LNFMA cement demonstrates excellent biocompatibility both in vitro and in vivo. The results showed that LNFMA monomer had optimized mechanical strength compared with previously reported NFMA monomers, and LNFMA bone cement had good antibacterial activity and biocompatibility.

Details

Language :
English
ISSN :
22968016
Volume :
11
Database :
Directory of Open Access Journals
Journal :
Frontiers in Materials
Publication Type :
Academic Journal
Accession number :
edsdoj.375c6007f2424286bdcc03661f86fbfc
Document Type :
article
Full Text :
https://doi.org/10.3389/fmats.2024.1432482