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Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

Authors :
Akiko Takahashi
Ryo Okada
Koji Nagao
Yuka Kawamata
Aki Hanyu
Shin Yoshimoto
Masaki Takasugi
Sugiko Watanabe
Masato T Kanemaki
Chikashi Obuse
Eiji Hara
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

The role of exosomes in intercellular communication is well established, however less in known about the biological roles of exosome secretion in exosome-secreting cells. Here the authors show that exosome secretion controls cellular homeostasis in exosome-secreting cells by removing harmful cytoplasmic DNA from cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.3766fd98b5947d28ef1846c81904cc6
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms15287