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Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

Authors :
Xiaodong Xie
Huifang Nie
Yu Zhou
Shu Lian
Hao Mei
Yusheng Lu
Haiyan Dong
Fengqiao Li
Tao Li
Bifei Li
Jie Wang
Min Lin
Chaihung Wang
Jingwei Shao
Yu Gao
Jianming Chen
Fangwei Xie
Lee Jia
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate them via the hepatobiliary route.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.37684587e3f4184b798b112c3849bf7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-13316-w