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Strategies to Improve Cannabidiol Bioavailability and Drug Delivery

Authors :
Saoirse Elizabeth O’Sullivan
Sanne Skov Jensen
Aditya Reddy Kolli
Gitte Nykjær Nikolajsen
Heidi Ziegler Bruun
Julia Hoeng
Source :
Pharmaceuticals, Vol 17, Iss 2, p 244 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The poor physicochemical properties of cannabidiol (CBD) hamper its clinical development. The aim of this review was to examine the literature to identify novel oral products and delivery strategies for CBD, while assessing their clinical implications and translatability. Evaluation of the published literature revealed that oral CBD strategies are primarily focused on lipid-based and emulsion solutions or encapsulations, which improve the overall pharmacokinetics (PK) of CBD. Some emulsion formulations demonstrate more rapid systemic delivery. Variability in the PK effects of different oral CBD products is apparent across species. Several novel administration routes exist for CBD delivery that may offer promise for specific indications. For example, intranasal administration and inhalation allow quick delivery of CBD to the plasma and the brain, whereas transdermal and transmucosal administration routes deliver CBD systemically more slowly. There are limited but promising data on novel delivery routes such as intramuscular and subcutaneous. Very limited data show that CBD is generally well distributed across tissues and that some CBD products enable increased delivery of CBD to different brain regions. However, evidence is limited regarding whether changes in CBD PK profiles and tissue distribution equate to superior therapeutic efficacy across indications and whether specific CBD products might be suited to particular indications.

Details

Language :
English
ISSN :
14248247 and 70901260
Volume :
17
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Pharmaceuticals
Publication Type :
Academic Journal
Accession number :
edsdoj.379f896fe3304b6a824b240a70901260
Document Type :
article
Full Text :
https://doi.org/10.3390/ph17020244