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The Effect of Physical Activity on Stress and Inflammation in Mice with Rheumatoid Arthritis
- Source :
- Journal of Ardabil University of Medical Sciences, Vol 24, Iss 1, Pp 92-106 (2024)
- Publication Year :
- 2024
- Publisher :
- Ardabil University of Medical Sciences, 2024.
-
Abstract
- Background: Rheumatoid arthritis is an autoimmune disease that gradually destroys the synovial joints and leads to chronic inflammation. This autoimmune disorder is associated with an increase in stress-related symptoms, including anxiety and depression, and a decrease in social behaviors, which severely reduces the patient's quality of life. Previous studies show that higher physical activity during adolescence may lead to a decrease in neurobehavioral disorders in adulthood. This study was conducted with the aim of evaluating the increase of physical activity from early adolescence on stress-related behaviors and inflammation in mice with rheumatoid arthritis. Methods: Male mice were randomly exposed to a running wheel from early adolescence to adulthood, and then rheumatoid arthritis was induced. Stress-related behaviors, including anxiety, depression and social behavior were investigated in animals. The level of interleukin 17 (IL-17) and interferon gamma (IFN-γ) were also measured as important inflammatory markers in the serum. Results: The results showed that physical activity from early adolescence significantly resulted in decreased stress in mice with rheumatoid arthritis. In addition, the running wheel led to a decrease in the levels of (IL-17) and (IFN-γ) in rheumatoid arthritis-induced mice as two important indicators of inflammation. Conclusion: This study shows that increased physical activity during adolescence to adulthood may make mice resistant to increased stress and inflammation caused by rheumatic arthritis.
- Subjects :
- exercise
stress
rheumatoid arthritis
inflammation
Medicine (General)
R5-920
Subjects
Details
- Language :
- Persian
- ISSN :
- 22287280 and 22287299
- Volume :
- 24
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Ardabil University of Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.37b1216db56451ebd0a9c3f3fb7a9d2
- Document Type :
- article