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Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Measuring precise protein turnover rates in animals is technically challenging at the proteomic level. Here, Fornasiero and colleagues use isotopic labeling with mass spectrometry and mathematical modeling to accurately determine protein lifetimes in the mouse brain
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.37f09442e22e41daa48bdc27c646c649
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-06519-0