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Concanavalin A-induced autoimmune hepatitis model in mice: Mechanisms and future outlook
- Source :
- Open Life Sciences, Vol 17, Iss 1, Pp 91-101 (2022)
- Publication Year :
- 2022
- Publisher :
- De Gruyter, 2022.
-
Abstract
- The concanavalin A (Con A)-induced liver injury mouse model is a typical animal model focusing on T cell-dependent hepatic damage in the field of autoimmune hepatitis (AIH). However, the underlying mechanism of hepatic dysfunction due to cell activation or signaling pathways triggered by Con A has not been fully clarified. Therefore, the controversy on this model remains in the academic community. In this article, we first summarized the merit and demerit of this contentious model from the perspectives of cell dysfunction, microcirculation disturbance, involved signaling pathways, as well as the properties of Con A. Then, we summed up the scientific implications of the model in elucidating the pathogenesis of AIH, and the shortcomings of this model were also summarized to elucidate the pathogenesis and application prospect of this classical liver injury mouse model in the study of AIH.
Details
- Language :
- English
- ISSN :
- 23915412
- Volume :
- 17
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Open Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.37fb0c53919d436fb670d27da7789979
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/biol-2022-0013