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Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse

Authors :
Anastasiia Bondarieva
Kavya Raveendran
Vladyslav Telychko
H. B. D. Prasada Rao
Ramya Ravindranathan
Chrysoula Zorzompokou
Friederike Finsterbusch
Ihsan Dereli
Frantzeskos Papanikos
Daniel Tränkner
Alexander Schleiffer
Ji-Feng Fei
Anna Klimova
Masaru Ito
Dhananjaya S. Kulkarni
Ingo Roeder
Neil Hunter
Attila Tóth
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Crossing over is a critical process during meiosis, although the regulation of this process still remains somewhat elusive. Here, the authors show that PRR19 partners with CNTD1 to enable formation of crossover-specific recombination complexes in mouse germ cells.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.380ea6fcb06a43c3808405a22b032e52
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-16885-3