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Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel

Authors :
Flavio Costa
Carlo Guardiani
Alberto Giacomello
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Costa et al. present the electro-mechanical coupling between the voltage sensor and pore domain of the hERG channel using a combination of molecular dynamics simulations and theoretical network analyses.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.386e4138c2e346888ac52b213eb55b94
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03074-9