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Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Dimethyl fumarate (DMF) is a major drug in the treatment of psoriasis and multiple sclerosis. Here the authors reveal a mechanism of RSK/MSK inhibition through covalent inhibition that can explain the observed clinical effects and the dose–response characteristics of DMF treatment.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.38a48876bc4d9fb74081c34943de76
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-06787-w