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Case report of the first cured patient with Mycobacterium Chimaera infection following cardiac valve replacement in the mainland of China

Authors :
Di Lu
Chun-Hong Zhang
Li-Jiang Chen
Pei-Feng Jin
Xia-Fei Feng
Xi Zhou
Wei-Cong Huang
Jue Wang
Ying Dai
Yun Fu
Source :
Antimicrobial Resistance and Infection Control, Vol 10, Iss 1, Pp 1-4 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background Mycobacterium chimaera infections subsequent to cardiac surgery are related to contaminated heater-cooler devices, with high mortality. Nevertheless, few studies have been reported in Asia. Case presentation We described the case of a 55-year-old man with Mycobacterium chimaera infection following cardiac surgery in the mainland of China. He was diagnosed with endocarditis caused by Mycobacterium chimaera subsequent to open heart surgery. Metagenomic next-generation sequencing (mNGS) and 16S rRNA gene PCR analysis were used to identify potential pathogens. The patient underwent redo valve replacement surgery and received combination therapy with azithromycin, ethambutol, linezolid, and amikacin. No signs of relapse were observed during the 11-month follow-up visit. Conclusions This is the first documented case of Mycobacterium chimaera infection following cardiac surgery in the mainland of China and the first documented transnational imported case worldwide. Moreover, mNGS is a novel diagnostic technology that can guide antimicrobial therapy prior to obtaining fluid/tissue culture results for Mycobacterium chimaera, providing a new approach for the detection of potential Mycobacterium chimaera infection.

Details

Language :
English
ISSN :
20472994
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Antimicrobial Resistance and Infection Control
Publication Type :
Academic Journal
Accession number :
edsdoj.38afe9f65f504adcb15a661f927f1dbf
Document Type :
article
Full Text :
https://doi.org/10.1186/s13756-021-01003-9